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the obstacle

已有 604 次阅读2010-9-27 09:35 |

and DPC three drug resistance, and other analyzed separately. INH, concentration, according to the national PAS resistance standard, divided into 1 muon g and 10 mu per milliliter 1 g, bound for resistance muon g, 1 muon g medicine under the strong growth is negative, not for sensitive bacteria. 1 mu for growth, g. positive for resistant pathogens. DPC concentrations, moncler because we still need to seek appropriate inhibitory concentration, into every milliliter medicated 0.1 muon g, 0.5 muon g, 1.0 muon g and 10 mu g four different concentrations. For convenience, with temporary statistic resistance standard as muon g, 1 muon g below for sensitive, 1 muon g of drug resistance.Table 1 30 cases of drug resistance analysisTraining result INH moncler jackets (PAS) %) (DPC)Sensitive 3 (10.0) and (73.3) 20 (66.6)Resistance 90.0 (8) (27) 10 (33.4) 26.7From table 1 shows resistant bacteria bead has reached 90% INH resistant strains, for 33.4%, the DPC statistical processing, X2 = 27.44, P < 0.001, a highly significant. By comparison with DPC PAS, chi-square statistics processing, calibration, P > 0.05 for naught, no significant.Table 2 sensitive moncler vest and drug resistance level of analysisTraining result INH PAS DPC(a) (3) (pore-filling 73.4%) 20) (66.6%.(+) 1 (3.3%) 2 (3) (pore-filling 6.6%)(+ +) (13.3%) 3 (4) 6 (20.0%) pore-filling(+ + +) and (3) (73.4% pore-filling) 1 (3.3%)Table 1 and table 2 can explain INH, PAS, DPC for three different kinds of anti-tuberculosis drugs, they are of different n/med tuberculosis bacterium, different moncler coats sensitive and drug resistance. From 8 cases of resistant strains PAS, we found that the 8 cases and three with anti-tuberculosis drugs resistance, resistance of 10 cases, strains DPC also have this phenomenon, is more resistant strains.Table 3 30 cases of DPC inhibitory concentration analysisInhibitory concentration (g) positive train speeds0.1 30 (100%) 0 (0%)0.5 18 (60%) 12 (40%),1.0 9 (30%) Cheap Moncler and (70),10.0 2 (28 (93.4%) 6.6 percent),From the table 3 shows, DPC inhibitory concentration, 1 muon g is 9 cases, still can cultivate 10 mu have 6.6 positive g.3 and discuss: in the past, people think DPC is a mixture of PAS INH +, we study from resistance and resistance level analysis, an independent DPC fight n/med tuberculosis medicaments, with Discount Moncler a PAS INH compounds, at present, our country resistant strains has reached 90%, INH resistance, so are still widely used, whether reduced efficacy, deserves attention. If, after the resistance INH irulence declined from us, all the time to look after training n/med tuberculosis bacterium growth, not the growth of bacteria. Statistically, resistance than strains, application of DPC INH still effective, Moncler Outlet the difference is highly significant. Therefore, as a DPC of another kind of anti-tuberculosis drugs, and such RFPS RFD, application, the key lies in whether the DPC, to RFPS PAS and RFD, absorption, can reduce the obstacle, reduce blood concentration RFPS. If not a DPC PAS metabolic phenomenon, DPC as another fight n/med tuberculosis medicaments, its application prospect is relatively Moncler Sale broad. Kowilsky's determination after taking blood concentrations of DPC, with the same amount of austenite with DPC, blood concentration INH 1 hour 5.8 mg/L, 3 hours 6mg / 4.56 mg/L 1,7 hours, 12 hours 2.6 mg/L, 14 hours 2mg/L, that's obviously superior DPC, its advantage is INH (1) DPC excretion, INH12 hours only 0.003 mg/blood concentration, and are still KPC

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